Benzon Symposium No. 47 Molecular Pharmacology of Ion Channels August 13-17, 2000 Copenhagen,
Denmark
Organizing committee:
Synopsis Activation of ion channels is essential for most cellular responses of both excitable and non-excitable cells. The primary structure of the protein building blocks of the majority of these ion channels has been determined, and different approaches have revealed detailed information on the mechanism of channel activation and regulation. In addition, structural elements defining the functional domain of the channel proteins have been identified and shown to exhibit structural homology between evolutionary distantly related channel proteins. Ion channels are targets for a large number of commonly used therapeutic agents. Many drugs act specifically on molecular subtypes of ion channels. The structural basis underlying the selectivity and the specific mode of action of a number of drugs have provided invaluable information on the molecular mechanism for ion channel activation and disclosed potential new targets for novel drugs. Moreover, genetic methods have provided the means to alter the pharmacological profile of ion channels and to study the animal behavioral effects of drugs. The aim of the symposium is to discuss the molecular mechanisms of ion channel activation and regulation with emphasis on molecular pharmacological approaches combined with "state of the art" molecular biological techniques.
Invited
speakers: Stephen
Heinemann, William N. Zagotta, Rolf Sprengel,
Hey-Kyoung Lee, Chris
Miller, R. Alan North, John Adelman, Juan Lerma Scientific
Programme Session
I: GLUTAMATE RECEPTORS I Stephen Heinemann:
Kainate Receptor-Deficient Mice Rolf Sprengel:
Importance of AMPA Receptors in Synaptic Plasticity Hey-Kyoung Lee:
Regulation of Glutamate Receptor Function and
Synaptic Plasticity Juan Lerma:
Kainate Receptors: New Functions, New Mechanisms Session
II: GLUTAMATE RECEPTORS II Eric Gouaux:
Action of Agonists and Antagonists on the GluR2
Ligand Binding Core Defined by X-ray Crystallography Jan Egebjerg:
Molecular Pharmacology of the Recombinant Glutamate
Receptors Mark Mayer:
Block of Glutamate Receptor Channels by Polyamines Poster
session (Posters Nos. 1-21 incl.) Session
III: NUCLEOTIDE-GATED
AND INHIBITORY RECEPTORS R.
Alan North:
Structure and Function in P2X Receptors Heinrich Betz:
Inhibitory and Excitatory Glycine Receptors:
Structures, Functions and Synaptic Localization Hanns
Möhler:
GABAA Receptor
Functions in vivo Revealed by Targeted Point
Mutations Bjarke Ebert:
GABAA Receptors: Determinants of Agonist Activity Session
IV: NICOTINIC ACETYLCHOLINE RECEPTORS Selected
oral presentations: Michael Hollmann:
Functional Concatemeric Glutamate Receptors Suggest
a Tetrameric Receptor Complex Stoichiometry (Poster
NO. 6) Bodo Laube:
Molecular Determinants of Agonist Discrimination in
the NR2B Subunit of the Excitatory NMDA Receptor
(Poster NO. 15) Roger L. Papke:
Kinetic Analysis of alpha7 nAChR Fast
Desensitization In Acutely Dissociated Hypothalamic
Neurons: Implications for Therapeutics (Poster NO.
30) Bruce Cohen:
Probing Potassium Channel Dynamics With a Unique
Intrinsic Fluorescence (Poster NO. 33) John A. Dani:
Nicotinic Cholinergic Mechanisms in the Central
Nervous System Arthur Karlin:
Gating and Electrostatics in the Acetylcholine
Receptor Channel Poster
session (Posters Nos. 22-37 incl.) Session
V: POTASSIUM CHANNELS I David Clapham:
Gbg
Regulated Ion Channels In Heart and Brain Senyon Choe:
Tetrameric Assembly of
Voltage-gated K+ Channels Chris Miller:
Structure-driven Investigations to Voltage-gated K+
Channels Frances Ashcroft:
Gating of the KATP Channel and Its
Modulation by Mg-Nucleotides Session VI:
POTASSIUM CHANNELS II John Adelman: Structure,
Function, and Physiology of Small and
Conductance Calcium-activated Potassium Channels Søren-Peter Olesen:
Molecular Pharmacology of Calcium-activated K+ Channels Michel Lazdunski:
2P-Domain K+ Channels: Structure,
Physiological Functions, Parmacology and Therapeutic
Implications Poster
session (Posters Nos. 38-59 incl.) Session
VII: CA-PERMEABLE CHANNELS Michael
Cahalan:
Cracking the Puzzles of CRAC, Ca2+ Release-activated
Ca 2+ Channels in Human T Lymphocytes William N. Zagotta:
Molecular Mechanisms of Gating in Cyclic
Nucleotide-gated Channels David Julius:
Ion Channels in the Pain Pathway Richard W. Tsien:
New Perspectives on Structure and Function of
Voltage-gated Calcium Channels Session
VIII: CHLORIDE AND SODIUM CHANNELS Selected
oral presentations: Andy Randall:
Electrophysiological Analysis of the Vanilloid
Receptor (VR1): Studies of Recombinant Receptors and
Knockout Mice (Poster NO. 66) Bernard Attali:
Modulation of the Cardiac IKS Channel
Gating: the Same IsK Residues Slow Activation and
Prevent Channel Inactivation (Poster NO. 38) Kamilla A. Pedersen:
A Novel Toxin-blocker of the ERG1 Channel (Poster
NO. 51) Carlo Brugnara:
Oral Administration of Novel Blocker of Erythrocyte
Cl-Conductance (NS3623) Reduces Sickle Cell
Dehydration and Sickling In Transgenic Sickle (SAD)
Mice (Poster NO. 69) Thomas J. Jentsch:
Diseases Due to Chloride and Potassium Channel
Mutations William A. Catterall:
Structure, Function, and Molecular Pharmacology
Voltage-gated Sodium Channels Poster
session (Posters Nos. 60-78 incl.) For Abstracts click here.
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